Pemphigus erythematosus - causes, symptoms, diagnosis and treatment

Pemphigus erythematosus (Seborrheic pemphigus, Senir-Usher syndrome) - clinical form of pemphigus that combines the true manifestations of pemphigus, seborrheic dermatitis and erythematous variant of systemic lupus erythematosus. Typical symptoms are erythematous pemphigus covered with thick crusts red lesion areas of the skin combined with seborrheic lesions on the scalp. It is characteristic for a long period of remission. Diagnosis of pemphigus erythematosus based on the study of smears and biopsies. Treatment is carried out glucocorticosteroids, extracorporeal blood correction methods, local administration and the imposition of glucocorticoid triamcinolone ointment.

  • Symptoms erythematous pemphigus
  • Diagnosis of pemphigus erythematosus
  • Treatment of pemphigus erythematosus
  • Pemphigus erythematosus - Treatment

  • Pemphigus erythematosus


    dermatology, pemphigus erythematosus is a clinical variant of true pemphigus, which is confirmed by the case of its transformation into a leaf-and pemphigus vulgaris. However, other researchers believe the disease variant of pemphigus foliaceous with mild. Localization erythematous pemphigus and the similarity of its manifestations on the scalp with a picture of seborrheic dermatitis were the basis for the second name of the disease - seborrheic pemphigus.

    hair loss leading to baldness.

    For a long time (an average of 5-7 years) pemphigus erythematosus symptoms affect only the scalp. In what could be the generalization process with the appearance of rashes on the skin of the interscapular area, chest and back. Located on the trunk erythematous patches covered with thick crusts, the removal of which causes pain to the patient. When removing stains from the surface crust beneath them found the open mouth of the hair follicles of the form Shipkov.

    Approximately 33% of patients with pemphigus erythematous skin manifestations of the disease are accompanied by lesions of the mucous membranes. There is a positive sign of Nikolsky. In some patients, the typical rash erythematous pemphigus combined with crusted papules or centers with typical greasy seborrhea well removes scales.

    dermatologist allow typical clinical presentation and localization of lesions. Confirm the diagnosis of a positive Nikolsky sign, identification of smears typical of pemphigus acantholytic cells, histological and immunological studies taken by biopsy material. Histological examination reveals the presence of bubbles and cracks in the stratum corneum and granular layers of the epidermis, follicular hyperkeratosis. During the direct immunofluorescence observed "lyupusnaya strip" running along the basement membrane, and intracellular accumulation of antibody in the epidermis. Indirect immunofluorescence also detects antibodies but does not "lyupusnoy band." In the blood of patients with pemphigus erythematous often detected characteristic of systemic lupus erythematosus antinuclear antibodies, antibodies to SS-A and ds DNA.

    The differential diagnosis of pemphigus erythematosus is carried out with seborrheic eczema, systemic lupus erythematosus, rosacea, actinic dermatitis, other forms of pemphigus, erythema multiforme exudative.

    stomach ulcer or ulcer disease 12P. ulcer drugs are administered intramuscularly. In generalized form to cleanse the patient's blood from circulating immune complexes in it shows the methods of extracorporeal blood correction: plasmapheresis, cascade plasma filtration, immunoadsorption, hemosorbtion, krioaferez. Local treatment of pemphigus erythematosus is the imposition of occlusive dressings with glucocorticoid ointments and intralesional triamcinolone administration.