Scientists spoke about the effect of sugar on the duration

British scientists from University College London found that eating large quantities of sugar as a child has a negative impact on health, resulting in reduced life expectancy. These conclusions were made on the basis of the experiment of the fruit fly Drosophila and the nematode worm.

"What we eat and ate in the past, has a profound and lasting impact on our health, and now we were able to discover the mechanism that controls this reaction. We assume that such" reprogramming "genes, which occurred in the body flies can occur . in the cells of other animals, we do not know, it is typical for a person or not, but everything speaks in favor of this "- says Adam Dobson.

Recent work by scientists focused on research to establish how calorie restriction or excess effect on life expectancy, and why chronic food shortages significantly prolongs the lives of many animals, such as the fruit fly Drosophila and rat, and almost no effect on the monkeys, and presumably , human.

The group of researchers led by Dobson found a possible answer to this question, watching the flies, fruit flies (Drosophila melanogaster). During the experiment, the experimental part fed "normal" with water content of 5 percent sugar, and the other - with a 40% syrup of sugar. Similarly, food scientists fed flies not permanently, but only three weeks during their youth, and then return them to a normal healthy diet.

As a result, investigators compared the activity of genes in cells and those of other flies, to see if the work diet and "readability" of genes changed, and what changes occurred in the whole body. As it turned out, even three weeks "sugar" diet was enough to irreversibly affect the work of several genes by modifying the activity of protein reading.

The suppression of one of them, of FOXO, a very negative impact on the life expectancy of flies - on average, the timing of their life decreased by 7%, even after they have returned to a healthy diet and do not overeat sugar. And the chances of increased die even in the "average" age, when the flies were still relatively young. In general, as noted by the researchers, the incidence of fatalities among healthy and "sugar" flies is correlated with corresponding statistics among lean and obese people.

"What we eat and ate in the past, has a profound and lasting impact on our health, and now we were able to discover the mechanism that controls this reaction. We assume that such" reprogramming "genes, which occurred in the body flies can occur . in the cells of other animals, we do not know, it is typical for a person or not, but everything speaks in favor of this "- says Adam Dobson.

A similar role, as shown by further experiments, of FOXO gene plays in the lives of other invertebrates - worms-nematodes Caenorhabditis elegans. When you add sugar to their food life is reduced in a similar manner. This further strengthened the confidence Dobson team that this region of DNA may play a regulatory role in life expectancy and in the human body.

It is possible that "repackaging" of FOXO will allow in the future to eliminate the negative effects of overeating sugar and obesity, the scientists conclude.