Vulnerability to infection depends on the time of day

The man is more vulnerable to infections during certain periods of the day, since the internal biological clock affects the ability of the virus to multiply and spread between cells. This is the conclusion, researchers from the University of Cambridge.

The results of this study may help explain why working people in different shifts, internal circadian rhythms that are constantly violated, are more prone to health problems, including infections and chronic diseases. When the virus enters the body, it breaks our cells and protect system resources in order to multiply and spread. However, these resources change during the day, partially correlating with circadian rhythms.

Circadian rhythms are our body control many physiological aspects - from sleep cycles and wake up to body temperature, the immune system to release hormones. In turn, these cycles are controlled by a number of genes including Bmal1 and Clock. In order to test the vulnerability of the circadian rhythm, the researchers compared the health of mice infected with the herpes virus at different times, evaluating indicators of viral infection and the rate of its spread.

All mice were living in a controlled environment in which the duration of the 12 day period was hours and the night - still 12. It was found that the spread of virus in mice infected at the beginning of the day, which was equivalent to the rising (in mice is the beginning of the rest period) was to 10 times stronger than that of mice that were infected by 10 hours when their body is shifted in the most active phase.

When this experiment was repeated among mice lacking Bmal1 virus propagation rate remains the same regardless of the time of penetration of the infection.