Scientists from the School of Medicine at Johns Hopkins University have used a special chemical "cocktail" for the rejuvenation of human embryonic stem cells (ESCs). According to EurekAlert !, obtained resulting material resembled their properties ESC mice. When in 1998 the researchers were able to obtain human ESCs, they noticed that they were significantly different from those of mice cells. ESC rodents could transform into any other cell and easy to genetic manipulation.
But it turned out that the lab environment to support human life is much more difficult ESC, and they can be converted only in certain types of cells. At the same time, scientists were able to uncover the reasons for this state of affairs after opened a new type of stem cells from mice. These cells were only a couple of days over conventional mouse ESC, however their properties are very much resembled "firmed" human embryonic stem cells. Thus, scientists realized that the latter are wear out "flexible" ESC and can rejuvenate.
Researchers rejuvenate cells managed by a special "3i-cocktail" which consists of three inhibitor compounds that are involved in the regulation of cellular interactions. The first drug inhibits signaling pathway WNT, which is responsible for embryogenesis and development of specialized cells and tumor growth. The second path off ERK, involved in the growth of tissue cells and increasing mobility. The latter material - tankirazy inhibitor - is an anticancer agent.
The mixture allows to transform the classic human ESCs, giving them the ability to turn into any cell in the body. In this case, there are no mutations that are a side effect of other reprogramming techniques.
Earlier it was reported that British scientists were allowed to use genetic engineering techniques to study the early stages of embryo development, aimed at improving fetal survival. Previously, the employee asked for permission to the London Institute of Francis Crick Kathy Niakan for the research project early stages of embryo development.