Scientists from Aarhus University in Denmark found that bacteria that can resist the effects of antibiotics, there are "palindromes" embedded in the amino acid sequences of some proteins. Effects on microorganisms would make them more susceptible to treatment. Their findings, researchers reported in an article published in the journal Nucleic Acids Research.
In order to survive under the action of antibiotics and the body's immune system, bacteria are able to go into a "sleep" state. One of the key components of this mechanism - the release of toxins produced by the bacterium itself, which inhibit the growth and development of microorganisms. However, under normal conditions of antitoxins are attached to toxins, which cut them, thereby making the active bacterium.
Scientists have found that the palindromic sequence of amino acids present in the antitoxin. In other words, they are the same when read from left to right or right to left. Palindromes helping protein change its configuration so that the two immediately deactivate the toxin molecule. Analysis of more than four thousand genomes of microorganisms showed that palindromes are used about a quarter of all known bacteria.
The researchers hope that the results obtained will help them create a new class of drugs that act on palindromes so as to prevent the release of toxins. This will make the treatment more effective antibacterial.