Hondromiksoidnaya fibroma - Causes, Symptoms, Diagnosis and Treatment

Hondromiksoidnaya fibroma - Hryascheobrazuyuschaya very rare benign tumor. Most often it occurs in the metaphysis and metadiaphysis long bones, but can grow and other bones of the skeleton. During usually beneficial, however, tends to recur, and in some cases may ozlokachestvlyatsya. Manifested gradually intensified pain in the affected area, in severe cases (especially in children) can be blurred or moderate atrophy of the muscles of the affected limb, and limitation of movement in the nearby joint. Surgical treatment is carried out in a planned manner. Running a radical removal of the tumor to prevent recurrence and malignant transformation. Weather favorable. Relapses occur in 10-15% of patients, usually - in the first two years after surgery.

  • Symptoms of fibroids hondromiksoidnoy
  • Diagnosis and differential diagnosis of fibroids hondromiksoidnoy
  • Treatment of fibroids hondromiksoidnoy
  • Hondromiksoidnaya fibroids - treatment

  • Hondromiksoidnaya fibroma


    orthopedic trauma or during radiographic examination.

    Usually it localized in the metaphyseal area metaepiphyseal and long bones of the lower extremities. The first place on prevalence takes hondromiksoidnaya fibroma of the proximal end of the tibia. Often found in the metatarsal bones and calcaneus. It is also possible defeat ribs, shoulder and pelvic bones and vertebrae, sternum and skull bones. 25% of the total number of cases accounted for the defeat of flat bones. The most aggressive growth of different tumor in the spine.

    enhondrome, benign and Chondroblastoma hondroblasticheskom variant of osteosarcoma, therefore performed a biopsy for definitive diagnosis. In the differential diagnosis in the first place should be excluded highly aggressive malignant chondrosarcoma.

    Macroscopically, the tumor tissue is lobed formation of a dense consistency bluish-gray or grayish-white, well-demarcated from healthy tissue. In their mind can resemble hyaline cartilage. Microscopic examination revealed myxoid or chondroid intercellular substance, inside of which there are elongated or stellate cells. Lots of connective tissue located primarily in interlayers between the slices. There's also found small vessels. In addition to the collagen fibers and osteoid detected multinucleated giant cells in the tumor tissue.

    The structure of the lobules within the same tumor can vary significantly. Identifies various fibroblasts - both large and small, some of the cells have 2 or 3 cores. The cells are located mainly at the periphery of the lobules. In every third case, the cells are benign fibroma hondromiksoidnoy atypical structure and in its cells resemble malignant chondrosarcoma. In 10% of cases are found in the biopsy foci of necrosis.

    During immunohistochemical studies revealed positive reaction with S-100 protein. Cells located on the periphery of lobules show immunoreactivity with CD 34 and smooth muscle actin. There cytoplasmic fibrils and cellular processes, there is the presence of glycogen. intermediate forms are found cells Along with typical myofibroblasts and chondrocytes.

    Treatment of fibroids hondromiksoidnoy



    Treatment with surgery alone. The operation is performed routinely in conditions oncology department. The most effective method of surgical intervention, providing the minimum number of relapses, a wedge resection of the affected area, followed by plastics defect auto- or allograft.

    In some cases, when the disease is carried out curettage (surgery in which the tumor scrape curette - a surgical instrument that looks reminiscent of a spoon). However, this approach is not preferred, since such interference increases with the probability that the affected area will remain in the modified tumor cells and hondromiksoidnaya fibroma relapses with time.

    Data on the probability of conversion hondromiksoidnoy fibroids malignant tumor mixed. This is due to a rare tumor and the possible overdiagnosis (cases where the results of microscopic examination of the removed tumor mistaken for a malignant because of similar cells). In general, the prognosis of this disease is considered to be favorable.